Pharmacokinetic Challenges in Drug Discovery (Ernst Schering Foundation Symposium Proceedings)

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This article describes recent advances in the prediction of physicochemical properties relevant to ADME such as lipophilicity , ADME properties themselves such as absorption , and toxicity issues such as drug—drug interactions.

Pharmacokinetic Challenges in Drug Discovery (Ernst Schering Foundation Symposium Proceedings)

In the next 10 years or so, the degree of automation in traditional drug metabolism departments will continue to increase and fully automated medium- and high-throughput in vitro assays will be used alongside in silico modelling and data interpretation. Kennedy, T. Drug Disc. Today 2 , — Van de Waterbeemd, H.

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Description

The power of prediction. Carlson, T.

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Predictive, computational models of ADME properties. Podlogar, B. Computational methods to estimate drug development parameters.

Bibliographic Information

Ekins, S. Progress in predicting human ADME parameters in silico. Application of in silico approaches to predicting drug—drug interactions. Methods 45 , 65—69 Rodrigues, A. Use of in vitro drug metabolism data to evaluate metabolic drug—drug interactions in man: the need for quantitative databases.

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Improvement in the handling of drug–drug interactions - Semantic Scholar

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Dill and S. Ex vivo NMR methods are complementary to in vivo measurements, as they can provide additional information and help in the interpretation of the in vivo data. Baszkin and W. Under normal oxygen tension, pyruvate would normally be converted to acetyl-CoA by pyruvate dehydrogenase, whose function is inhibited by PDK1-mediated phosphorylation. Cell Proliferation and Apoptosis. Bibliometric analysis of 19 anti-cancer drug publications produced 28, papers for analysis. Domain Motions.

Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties. Kulkarni, A.

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Predicting Caco-2 cell permeation coefficients of organic molecules using membrane-interaction QSAR analysis. Cummins, C. Gumbleton, M. Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier.

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Agatonovic-Kustrin, S.